uBiome, Inc. was a biotechnology company based in San Francisco, California, founded in 2012. It offered direct-to-consumer microbiome sequencing services, allowing individuals to explore the microorganisms living in and on their bodies. Their products included kits like SmartGut™ for gut health and SmartJane™ for vaginal health. The company raised significant venture capital and aimed to build the world's largest human microbiome database. However, uBiome faced intense scrutiny over its billing practices and the medical necessity of its tests, leading to an FBI investigation, the ousting of its founders, and eventual bankruptcy in 2019. Its assets, including its patent portfolio and microbiome database, were later acquired by Psomagen (formerly Macrogen Clinical Laboratory) in 2020.
Served as the central hub for research and development, laboratory operations (though some lab work was outsourced or done in other facilities), marketing, sales, and administrative functions.
The headquarters likely featured modern office spaces and potentially in-house laboratory facilities for sample processing and sequencing, typical of a biotech startup in the area.
Likely a fast-paced startup environment, initially driven by innovation and a mission to democratize microbiome science. As the company grew rapidly, pressures to meet targets may have influenced the culture, particularly leading up to its controversies.
The San Francisco HQ was central to uBiome's operations, fundraising efforts, and public image as a cutting-edge biotech firm in Silicon Valley.
uBiome's primary operations were concentrated in the United States, particularly California. While they marketed and shipped their testing kits to customers internationally, their physical office presence outside the US was minimal, possibly including a small R&D or support office in Chile. Their main global interaction was through the sale and distribution of their testing kits and the collection of microbiome data from a global user base.
246 1st St, Floor 6
San Francisco
CA
USA
Address: Specific address not readily available. Likely a small research or development office.
May have been established for talent acquisition or specific R&D collaborations in South America.
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As of April 2025, uBiome' leadership includes:
uBiome has been backed by several prominent investors over the years, including:
The most significant executive changes at uBiome involved the co-founders, Jessica Richman and Zachary Apte, who were ousted in 2019 amid investigations into the company's billing practices. They were later indicted on federal charges. The company filed for bankruptcy, leading to a complete dissolution of its executive team.
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As uBiome is no longer operational, its corporate email system is defunct. Historically, like many tech companies, uBiome likely used common email patterns. These formats are no longer active.
Common formats included [first].[last]@ubiome.com or [first_initial][last]@ubiome.com.
Format
jane.doe@ubiome.com or jdoe@ubiome.com
Example
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Success rate
FierceBiotech • October 29, 2018
uBiome announced an $83 million Series C funding round, led by OS Fund, to expand its clinical tests, therapeutics development, and its microbiome database....more
The Wall Street Journal • April 26, 2019
The FBI conducted a raid on the headquarters of uBiome as part of an investigation into the company's billing and marketing practices....more
STAT News • October 2, 2019
uBiome filed for Chapter 11 bankruptcy protection following months of scrutiny, an FBI raid, and the ousting of its co-founders....more
U.S. Department of Justice • March 18, 2021
Jessica Richman and Zachary Apte, co-founders of uBiome, were indicted on multiple federal charges, including conspiracy to commit securities fraud, conspiracy to commit health care fraud, and money laundering....more
GenomeWeb • January 15, 2020
Psomagen (then Macrogen Clinical Laboratory) acquired uBiome's patents, data, and lab equipment for $7.1 million in a bankruptcy auction....more
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